Low to moderate sugar-sweetened beverage consumption impairs glucose and lipid metabolism and promotes inflammation in healthy young men: a randomized control trial.
Aeberli I, Gerber PA, Hochuli M et al (2011) American Journal of Clinical Nutrition 94: 479-85
Objective: To investigate the effects of SSB consumption over 3 weeks on LDL particle distribution and various parameters of glucose and lipid metabolism and inflammation in healthy young men.
Design: Randomized, controlled cross over trial. Six three-week interventions, involved consuming 600 ml per day of a SSB, 200 ml with each main meal. 40 g fructose/day (medium fructose MF), 80 g fructose /day (HF)40 g glucose/day (MG), 80 g glucose/day (HG), 80 g sucrose/day (HS), Control advised to minimize all fructose intake (LF)
Setting: Zurich, Switzerland
Participants: 29 healthy normal weight volunteers aged 19-25
Main outcome measures: Weight, waist circumference, BP, LDL size, LDL subclasses (%), CRP fasting glucose, postprandial glucose.
Results: No differences in conventional lipid profile or in blood pressure, body weight or waist circumference. Mean overall LDL size reduced after HF and HS. LDL particle distribution shifted after MF, HF and HS. Fasting glucose raised after all interventions. Postprandial glucose lower after all interventions compared with LF control
Conclusions: Potentially harmful effects from low to moderate consumption of SSBs
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