Relevance of liver fat to the impact of dietary extrinsic sugars on lipid metabolism

Griffin,B.A., (2015) Proc.Nutr.Soc. 74:208-214 10.1017/S0029665115002050

OBJECTIVE: Review addressing the variable metabolic origins of liver fat, the importance of postprandial lipid metabolism in relation to liver fat, and the effects of supra-physiological intakes of sugar compared with the established threshold for the adverse effects of sugar on cardio-metabolic risk factors. More “Relevance of liver fat to the impact of dietary extrinsic sugars on lipid metabolism” >

Associations between dietary intake and the presence of the metabolic syndrome in patients with non-alcoholic fatty liver disease

Georgoulis,M., Kontogianni,M.D., Margariti,A., et al, (2015) J.Hum.Nutr.Diet. 10.1111/jhn.12323

OBJECTIVE: To evaluate the presence of the metabolic syndrome (MetS) and its individual components and to explore their potential associations with dietary habits in terms of food or food group consumption, as well as adherence to the Mediterranean diet, in a sample of non-alcoholic fatty liver disease (NAFLD) patients. More “Associations between dietary intake and the presence of the metabolic syndrome in patients with non-alcoholic fatty liver disease” >

Childhood energy intake is associated with nonalcoholic fatty liver disease in adolescents

Anderson,E.L., Howe,L.D., Fraser,A., et al, (2015) J.Nutr. 145:983-989 10.3945/jn.114.208397

OBJECTIVE: To determine prospective associations between childhood energy intake and markers of non-alcoholic fatty liver disease (NAFLD) in adolescents and to determine whether any observed associations were mediated through total body fat at the time liver outcomes were assessed. A secondary objective was to explore whether different macronutrients and their subgroups may be driving any associations between energy intake and liver outcomes. More “Childhood energy intake is associated with nonalcoholic fatty liver disease in adolescents” >

Childhood adiposity trajectories and risk of nonalcoholic fatty liver disease in adolescents

Ayonrinde,O.T., Olynyk,J.K., Marsh,J.A., et al, (2015) J.Gastroenterol.Hepatol. 30:163-171 10.1111/jgh.12666

OBJECTIVE: To examine and identify associations between anthropometry at different time points, adiposity trajectories from birth through childhood and adolescence, and a subsequent diagnosis of non-alcoholic fatty liver disease (NAFLD) at 17 years of age. More “Childhood adiposity trajectories and risk of nonalcoholic fatty liver disease in adolescents” >

Higher fructose intake is inversely associated with risk of nonalcoholic fatty liver disease in older Finnish adults

Kanerva,N., Sandboge,S., Kaartinen,N.E., Mannisto,S. and Eriksson,J.G., Am.J.Clin.Nutr. 100:1133-1138 (2014) 10.3945/ajcn.114.086074

OBJECTIVE: To explore associations between fructose intake and NAFLD, measured by the Fatty Liver Index (FLI) and the NAFLD liver fat score on the basis of blood measurements, in a cohort of ~2000 older adults.

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Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis

Chung,M., Ma,J., Patel,K., Berger,S., Lau,J. and Lichtenstein,A.H., (2014) Am.J.Clin.Nutr. ajcn.086314

OBJECTIVE: To examine the effect of different amounts and forms of dietary fructose, sucrose, HFCS and SSB (if absolute amount of fructose or sucrose was reported) on the incidence or prevalence of NAFLD and indexes of liver health in humans. Fructose included both free fructose and total fructose (including honey).

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A Cross-Sectional Study Assessing Dietary Intake and Physical Activity in Canadian Patients with Nonalcoholic Fatty Liver Disease vs Healthy Controls

Da Silva,H.E., Arendt,B.M., Noureldin,S.A., Therapondos,G., Guindi,M. and Allard,J.P., (2014) J.Acad.Nutr.Diet. 114:1181-1194 10.1016/j.jand.2014.01.009

OBJECTIVE: To compare the diet and physical activity of healthy controls and of patients with NAFLD vs current recommendations.

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Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials

Chiu,S., Sievenpiper,J.L., de Souza,R.J., et al,. (2014) Eur.J.Clin.Nutr. 10.1038/ejcn.2014.8

OBJECTIVE: A systematic review and meta-analysis of controlled feeding trials examining the effect of fructose on markers of NAFLD in humans.

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No Difference Between High-Fructose and High-Glucose Diets on Liver Triacylglycerol or Biochemistry in Healthy Overweight Men

Johnston,R.D., Stephenson,M.C., Crossland,H., et al, (2013) Gastroenterology 10.1053/j.gastro.2013.07.012


Objective: To compare the effects on liver fat levels of glucose and fructose under either isocaloric or hypercaloric conditions

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